Survodutide Phase 2 Trial Results

Survodutide Phase 2 Trial Results

Survodutide is a dual Glucagon and Glucagon-Like Peptide 1 agonist which interacts with hormone receptors in your body to help reduce food cravings, and encourage weight loss.

Don't know what a GLP1 Receptor Agonist is, or how drugs like Ozempic, Mounjaro, Wegovy, or Zepbound work?

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Similar to drugs like Ozempic, Wegovy, Zepbound, Mounjaro and others, Survodutide helps people lose weight and maintain a healthy weight, by mimicking the body's natural peptides with synthetic form(s).

A research paper recently published in the New England Journal of Medicine reviews the finding of the study and the results:

A Phase 2 Randomized Trial of Survodutide in MASH and Fibrosis - PubMed
Survodutide was superior to placebo with respect to improvement in MASH without worsening of fibrosis, warranting further investigation in phase 3 trials. (Funded by Boehringer Ingelheim; 1404-0043 number, NCT04771273; EudraCT number, 2020-002723-11.).


The study found:

  • Improvement in Fatty Liver disease (NASH/MASH) with no worsening of Fibrosis
    • 37% for participants taking 2.4mg dosage
    • 62% for participants taking 4.8mg dosage
    • 43% f0r participants taking 6.0mg dosage
    • 14% of participants in the placebo (not given the drug)
  • Decrease in liver fat content 0f at least 30%
    • 63% for participants taking the 2.4mg dosage
    • 67% for participants taking the 4.8mg dosage
    • 57% for the participants taking the 6.0mg dosage
    • 14% of participants in the placebo (not given the drugs)

Clearly, Survodutide does improve outcomes for people with fatty liver disease (NASH/MASH) and does so much better than placebo.

Study: Survodutide for people with Fatty Liver (NASH/MASH)

Link to the full study

NASH/MASH (metabolic dysfunction–associated Steatohepatitis) is also known as "fatty liver disease", and is a condition that often affects people with Type 2 Diabetes (for which drugs like Survodutide or other GLP1 agonists are prescribed)

Metabolic dysfunction–associated steatotic liver disease - Wikipedia

The study found that:

A total of 293 randomly assigned participants received at least one dose of survodutide or placebo. Improvement in MASH with no worsening of fibrosis occurred in 47% of the participants in the survodutide 2.4-mg group, 62% of those in the 4.8-mg group, and 43% of those in the 6.0-mg group, as compared with 14% of those in the placebo group (P<0.001 for the quadratic dose–response curve as best-fitting model).

A decrease in liver fat content by at least 30% occurred in 63% of the participants in the survodutide 2.4-mg group, 67% of those in the 4.8-mg group, 57% of those in the 6.0-mg group, and 14% of those in the placebo group; improvement in fibrosis by at least one stage occurred in 34%, 36%, 34%, and 22%, respectively. Adverse events that were more frequent with survodutide than with placebo included nausea (66% vs. 23%), diarrhea (49% vs. 23%), and vomiting (41% vs. 4%); serious adverse events occurred in 8% with survodutide and 7% with placebo.

NASH/MASH was improved in substantial amounts of the participants in the study, compared to Placebo.

Here is a direct link to the trial, ID NCT04771273 (sponsored by Boehringer):

Boehringer Ingelheim was happy to tout the success of the phase 2 trials in their announcement of seeking phase 3 trials.

Who makes Survodutide?

Survodutide was developed by by Boehringer Ingelheim

Boehringer Ingelheim to Advance Survodutide into Three Global Phase III ...
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Boehringer Ingelheim - Wikipedia