Pfizer ends development of oral GLP1 Danuglipron
Amid heavy competition in GLP1 development, Pfizer gives up on the promise of Danuglipron, citing issues with liver related side-effects.

GLP1 Receptor Agonists are very valuable drugs, both to consumers who want help with weight management or type 2 diabetes, and companies that are looking for profitable drug candidates. Despite this, not every GLP1 formulation makes it to market.
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While intense competition can breed higher quality drugs, it can cause overlooking of deficiencies in existing formulations in a rush to get to market. Thanks to vigilance on the part of (and likely some competitive pressures), Danuglipron is not one of those cases.
The end of Danuglipron as a possible future GLP1 that increases accessibility and drives down prices is regrettable, but the continuation of GLP1 as an incredibly safe and well-researched choice for weight management and treatment of type 2 diabetes is worth celebrating.
Want to ready the reasons we found as to why Danuglipron is no longer developed? The rest of this article is no longer available for free – if you'd like to read the rest of our analysis, check us out on Substack: